By screening over 40,000 compounds, a team led by Biology’s Keith Choe, discovered that a novel metal homeostasis protein in C. elegans functions as a resistance mechanism to pre-clinical anticancer fungal toxins.
The team also made the cover of the journal: ACS Chemical Biology: In vivo screening of 41716 compounds in the nematode Caenorhabditis elegans identifies pre-clinical anticancer mycotoxins chaetocin and chetomin as potent inducers of novel nuclear metal homeostasis protein NUMR-1/2 in the alimentary canal. Chaetomiaceae fungi and C. elegans inhabit similar environments, raising the possibility that NUMR-1/2 functions as a resistance mechanism.
https://pubs.acs.org/toc/acbcct/19/5/
