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Malcolm Maden

Professor

Ph.D. University of Birmingham, UK, 1975

maden326 Bartram Hall
(352) 392-5856
—and—
415 Cancer & Genetics Research Complex
(352) 273-7875
malcmaden@ufl.edu

Research Interests

I study the relationship between development and regeneration in various organ systems including the limb, the lung, the skin and the nervous system. The guiding principle of this research is that by comparing the signaling molecules that operate in these two processes we can determine whether there are any fundamental differences (is regeneration a process of re-development?) and whether we can induce regeneration by re-awakening developmental pathways. Much of this work is centered on one signaling pathway, that of retinoic acid and the organisms used range from axolotls (the champion of regeneration) to mice. Most recently we have discovered that the spiny mouse can regenerate its skin wounds perfectly by replacing hairs, sebaceous glands, dermis, smooth muscle and skeletal muscle and much of our work is now concerned with what seems to be a remarkable regenerating mammal.

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Representative Publications

On skin regeneration:
  • SEIFERT, A.W. & MADEN, M. (2014). New insights into vertebrate skin regeneration. Int. Rev. Cell Mol. Biol. 310, 129-169.

    BRANT J.O., LOPEZ, M-C, BAKER, H.V., BARBAZUK, W.B. & MADEN, M. (2015). A comparative analysis of gene expression profiles during skin regeneration in Mus and Acomys. PlosOne Nov 25;10(11):e0142931

    BRANT, J.O., YOON, J.H., POLVADORE, T., BARBAZUK, W.B. & MADEN, M. (2016). The cellular basis of scar-free skin regeneration in the spiny mouse. Wound Rep Regen 24(1), 75-88.

  • SEIFERT, A,W., KIAMA, S.G., SEIFERT, M.G., GOHEEN, J.R., PALMER, T.M. & MADEN, M. (2012). Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature 489, 561-5.
  • SEIFERT, A.W., MONAGHAN, J.R., VOSS, S.R. & MADEN, M. (2012). Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebrates.PLoS One 7, e32875.
On limb regeneration:
On nervous system regeneration and maintenance:
  • MADEN, M (2015). Retinoic acid signaling and central nervous system development. In “THE RETINOIDS, Biology, Biochemistry and Disease”, eds P. Dolle & K. Niederreither. Wiley-Blackwell, New Jersey. Pp 309-338.

    MADEN, M., MANWELL, L.A. & ORMEROD, B.K. (2013). Proliferation zones in the axolotl brain and regeneration of the telencephalon. Neural Dev. 8, 1.

  • JARVIS, C.I., GONCALVES, M.B., CLARKE, E., DORGUEL, M., KALINDJIAN, S.B., THOMAS, S.A., MADEN, M. & CORCORAN, J.P.T. (2010). Retinoic acid receptor-a signalling antagonizes both intracellular and extracellular amyloid-b production and prevents neuronal cell death caused by amyloid-b. Eur. J. Neurosci. 32, 1246-1255.
  • AGUDO, M., YIP, P., DAVIES, M., BRADBURY, E., DOHERTY, P., MCMAHON, S., MADEN, M. & CORCORAN, J.P. (2010). A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. Neurobiol. Dis. 37, 147-155.
  • MADEN, M. (2007). Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat. Rev. Neurosci. 8, 755-65.
  • PO, S.L., YIP, P.K., BUNTING, S, WONG, L-F., MAZARAKIS, N.D., HALL, S.,MCMAHON, S., MADEN, M. & CORCORAN, J.P. (2006). Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth. Dev. Biol. 298, 167-175.
  • YIP,P.K., WONG, L-F., PATTINSON, D., BATTAGLIA, A., GRIST, J., BRADBURY, E.J., MADEN, M., MCMAHON, S.B. & MAZARAKIS, N.D. (2006). Lentiviral vector expressing retinoic acid receptor b2 promotes recovery of function after corticospinal injury in the adult rat spinal cord. Human Mol. Genet. 15, 1-12.
  • MADEN, M. (2006). Retinoids and the spinal cord. J. Neurobiol. 66, 726-738.
On lung regeneration:
  • HIND, M. & MADEN, M (2011). Is a regenerative approach viable for the treatment of COPD?.  Br. J. Pharmacol. 163, 106-15.
  • HIND, M., GILTHORPE, A., STINCHCOMBE, S.V. & MADEN, M. (2009). Retinoid induction of alveolar regeneration: from mice to man? Thorax 64, 451-457.
  • STINCHCOMBE, S.V. & MADEN, M. (2008). Retinoic acid induced alveolar regeneration: critical differences in strain sensitivity. Am. J. Respir. Cell Mol. Biol. 38, 185-91.
  • MADEN, M. (2006). Retinoids have differing efficacies at inducing alveolar regeneration in a dexamethasone treated mouse model. Am. J. Resp. Cell Mol Biol. 35, 260-267.
On development:
  • REIJNTJES, S., ZILE, M.H. & MADEN, M. (2010). The expression of Stra6 and Rdh10 in the avian embryo and their contribution to the generation of retinoid signatures. Int. J. Dev. Biol. 54, 1267-1275.
  • WILSON, L.J., MYAT, A., SHARMA, A., MADEN, M. & WINGATE, R.J.T. (2007). Retinoic acid is a potential dorsalising agent in the late embryonic chick hindbrain. BMC Dev. Biol. 7, 138.
  • CHAMBERS, D., MADEN, M. & LUMSDEN, A. (2007). RALDH-independent generation of retinoic during vertebrate embryogenesis by CYP1B1. Development 134, 1369-1383.
  • MADEN, M., BLENTIC, A., REIJNTJES, S., SEGUIN, S., GALE, E. & GRAHAM, A. (2007). Retinoic acid is required for specification of the ventral eye field and for Rathke’s pouch in the avian embryo. Int. J. Dev. Biol. 51, 191-200.
  • REIJNTJES, S., RODAWAY, A. & MADEN, M. (2007). The retinoic acid metabolizing gene, CYP26B1, functions in zebrafish to pattern the cranial neural crest. Int. J. Dev. Biol. 51, 351-360.
  • MADEN M. (2006). Analysis of retinoid signaling in embryos. In Growth Factor Signaling in the Embryos. M.Whitman & A.K.Slater (eds) pp87-128. CRC Press, Boca Raton, Florida.