Ph.D., King’s College, London
512 Carr Hall
I study the relationship between evolution, development and regeneration in a range of vertebrate structures, including teeth, skin appendages and sensory structures. The work in the Fraser Lab is centered on the study of a selection of intriguing fish models of evolutionary developmental biology (EvoDevo), including pufferfish, cichlids and sharks. Some of our most recent projects have focused on tooth regeneration and we have discovered stem cell niches associated with the continuously regenerative dentition of sharks, and the tooth-to-beak transition that occurs during pufferfish development. Our lab is interested in how vertebrates make, shape and regenerate complex morphologies. We have also recently discovered that shark skin teeth (denticles) develop via a highly conserved Turing-like patterning mechanism; a developmental process shared with bird feather and mammalian hair development.
RL Cooper, AP Thiery, AG Fletcher, DJ Delbarre, LJ Rasch, GJ Fraser. (2018). An ancient Turing-like patterning mechanism regulates skin denticle development in sharks Science Advances. 2018 Nov 7;4(11): eaau5484.
AP Thiery, T Shono, D Kurokawa, R Britz, Z Johanson, GJ Fraser (2017). Spatially restricted dental regeneration drives pufferfish beak development Proceedings of the National Academy of Sciences. 114 (22), E4425-E4434
KJ Martin, LJ Rasch, RL Cooper, BD Metscher, Z Johanson, GJ Fraser (2016). Sox2+ progenitors in sharks link taste development with the evolution of regenerative teeth from denticlesProceedings of the National Academy of Sciences. 113 (51), 14769-14774
LJ Rasch, KJ Martin, RL Cooper, BD Metscher, CJ Underwood, GJ Fraser (2016). An ancient dental gene set governs development and continuous regeneration of teeth in sharks Developmental Biology. 415 (2), 347-370
ZOO6927 – Neuro-Evo-Devo
ZOO3713C – Functional Vertebrate Anatomy